| Open in Read by QxMDĢ011 Clinical Practice Guide on Anticoagulant Dosing and Management of Anticoagulant Associated Bleeding Complications in Adults.Īwad NI, Cocchio C. Assessing bleeding risk in patients taking anticoagulants. Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage.

| Open in Read by QxMDįrontera JA, Lewin III JJ, Rabinstein AA, et al. How to effectively manage the event of bleeding complications when using anticoagulants. Nonspecific reversal agents like 4-factor prothrombin complex concentrate ( PCC), activated PCC, recombinant activated factor VII, thrombocyte concentrates, and fresh frozen plasma have procoagulatory effects! Before these drugs are administered, the increased risk of thrombosis should be carefully weighed against the risk of ongoing bleeding. Andexanet alfa (inactive, recombinant factor Xa).Rivaroxaban: 5–9 hours ( 11–13 hours in elderly).Idarucizumab ( monoclonal antibody Fab fragments).Activated prothrombin complex concentrate ( aPCC).Synthetic pentasaccharide factor Xa inhibitors 4-factor prothrombin complex concentrate ( PCC rapid reversal).

Antidote for warfarin overdose